In 1978, the son of criminal lawyer Eustacchio Sisto graduated in law with top marks and honours from the University of Bari, discussing a thesis in criminal law with Professor Renato Dell'Andro, whose teaching and university research he studied.

He has been working as a solicitor since 1981 and a lawyer since 1995. After a brief stint as a visiting professor at the Faculty of Economics at the University of Bari, he has been teaching Criminal Law for Occupational Health and Safety at the Politecnico di Bari, Italy since 1994.

He has also held teaching positions at the Faculty of Medicine and the Faculty of Law at the University of Bari.

He is the author of numerous scientific publications and a regular speaker at legal conferences on criminal and constitutional issues.

He is the owner, in Bari, of FPS Law Firm.

In 2003, he was appointed consultant of the Bicameral Commission for the investigation of the Cermis tragedy. In 2004, he was appointed consultant of the Parliamentary Anti-Mafia Commission.

In 2005, he was appointed by the Minister of Health as Extraordinary Commissioner at the "De Bellis" Scientific Institute for Research and Treatment in Castellana Grotte (Ba).

In 2008, 2013 and 2018 he was elected, in the Puglia constituency, as a Member of the Italian Parliament, a role he still currently holds.

In this capacity, he holds the positions of Vice-President of the Committee for Authorisations, member of the II Commission for Justice, member of the Bicameral Commission on Anti-Mafia Investigation and member of the Parliamentary Committee for Indictment Proceedings.

In this capacity, he has been the presenter and rapporteur, among others, of legislative measures on constitutional reform, the judiciary, public safety, company law, medical professional liability and family law.

In this capacity, he has held the positions of President of the I Commission for Constitutional Affairs, Vice-President of the Committee for Authorisations, Member of the II Commission for Justice, Member of the Bicameral Commission of Anti-Mafia Enquiry and Member of the Parliamentary Committee for Indictment Proceedings.

He was also a member of the Commission of Inquiry into the kidnapping and death of Aldo Moro.

He was President of the Judicial Commission for Personnel of the Chamber of Deputies, member of the I Commission for Constitutional Affairs of the Presidency of the Council and Interior, member of the Committee for Authorisations and of the Parliamentary Committee for Indictment Proceedings.

He has followed and is following criminal trials of national importance.

From March 1, 2021 to October 15, 2022 he was Under-Secretary of State for Justice.

On 25 September (fourth parliamentary mandate) he was elected Senator of the Republic in the Collegio Puglia 2.

From October 31, 2022 to December 15, 2022 he was Under-Secretary of State for Justice.

Since December 15, 2022 he is Deputy Minister of Justice.